In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells
Moreover, a significant 3% reduction in skeletal muscle mass was observed
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[11] Additionally, Rich suggested avoiding choline or TMG supplementation, as it could push the BHMT pathway at the expense of the methionine pathway, and to avoid over-supplementing with different forms of folate that would compete for absorption