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One review recommended the following regimen for patients with valproic acid overdose: 100 mg/kg IV loading dose followed by 50 mg/kg (maximum of 3 grams) IV every 8 hours until the ammonia levels are decreasing and the patient is improving [3]

Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT

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[DOI] [PubMed] [Google Scholar] Mnzel T, Gori T, Keaney JF, Jr, Maack C, Daiber A

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