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Long-term studies show that continuous drug dependence, gastrointestinal side effects, and rebound weight gain are common once treatment stops

Brand-name FDA-approved alternatives exist at dramatically higher prices and with insurance/prior-authorization barriers

Adequate protein supports collagen production and keratin formation, which may help reduce shedding and support healthier skin during weight loss

Instead, it exemplifies how endogenous peptides exhibiting multi-receptor activity were historically disadvantaged by a development paradigm that prioritized single-target selectivity over physiological relevance

And importantly, this should not be framed as an anti-GLP-1 conversation

The most effective FDA-approved options for weight loss are tirzepatide (Mounjaro/Zepbound) and semaglutide (Ozempic)