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Furthermore, while probiotics had no effect on VDR (-/-) mice, they were demonstrated to provide physiological and histologic protection against Salmonella-induced colitis in VDR (+/+) animals (187)

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Increased oxidative stress, inflammation and lipotoxicity associated with hyperglycaemia and insulin resistance potentially impair vascular endothelial function and increase endothelial permeability, leading to the penetration of glycated and oxidized low-density lipoprotein (LDL) cholesterol into the endothelium, i.e., initiation of atherosclerosis