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Clinical studies show tirzepatide provides superior A1C reduction (up to 2.4% decrease) and weight loss compared to semaglutide, but requires careful monitoring for hypoglycemia, especially in patients on insulin or sulfonylureas

By contrast, a recent clinical trial by Eli Lilly tracked nearly 400 subjects who switched from shots to Foundayo, and found that on average, they maintained most of their weight loss after 52 weeks

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The price of these drugs is completely in flux, Cotter said

According to the authors, liraglutide taken as a monotherapy or as an add-on could significantly improve insulin resistance compared to controls