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Effect persistence monitoring: because effects outlast serum presence, endpoint timing should reflect biological process kinetics (days-weeks) rather than serum PK kinetics (hours)

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Animal studies in db/db mice revealed that MitoQ reversed mitochondrial fragmentation, reduced ROS overproduction, and restored PINK1/Parkin-mediated mitophagy, accompanied by suppressed NLRP3 inflammasome activation and decreased secretion of pro-inflammatory cytokines

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