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According to the manufacturer, Wegovy can be stored safely between 8C and 30 C, so long as the cap hasn't been removed and it's kept in the box away from light

This can happen with deeper injections, such intramuscular or intravenous injections

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Counterintuitively, mice completely defective for the GLP-1 receptor were reported to be protected from high-fat diet-induced peripheral Insulin resistance (177) and, consistently with this, central inhibition of GLP-1R signaling with the antagonist exendin 9-39 improves glucose tolerance and glycaemia (178)