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P = 0.001 and significant treatment x time interaction, F 32,240 = 4.18

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In the 10-h Esm1 lineage tracing experiment using E14.0 embryonic intestine, total ERG + , ERG + Esm1 + , ERG + GFP + , and ERG + Esm1 + GFP + cells were quantified using Photoshop and ImageJ software