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Neurological damage that has been present for more than six months may show limited or incomplete recovery, highlighting the importance of early diagnosis and treatment
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[PMC free article: PMC6208583] [PubMed: 29926323] 16
Interestingly, another mechanism was proposed as an alternative way to stabilize NRF2 through the interaction between the autophagy adaptor protein p62/sequestosome-1 (p62/SQSTM1) and KEAP1, which leads to the sequestration of KEAP1 in the autophagy-deficient cells and enables NRF2 accumulation [20]