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26 Within the TME, cancer cells can establish an immunosuppressive metabolic microenvironment by depriving immune cells of vital metabolites such as glucose and oxygen while also elevating the levels of mediators such as lactate and adenosine that limit the function of immune cells

A well-functioning anus contributes to a healthy gut microbiome, as the timely expulsion of stool prevents the buildup of harmful bacteria

Side effects of injectable B12 may include such gastrointestinal symptoms as nausea, vomiting, mild diarrhea, headache and dizziness, skin rash, and itching (presumably, related to skin rash)

Naldemedine: a review in opioid-induced constipation

Related work showed context-appropriate angiogenesis during muscle/tendon healing, with VEGF-linked markers in vivo (Brcic 2009)