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2004 May;15(5):712-20

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qRT-PCR analysis (Figure 2E) showed that FOXO4-DRI-treated PDL9 cells displayed enhanced SOX9 expression, and reduced MMP12 and MMP13 expression, which however were at the expense of lower expression levels of COL2

The effects are more pronounced in older patients, who already experience age-related collagen and elastin depletion

however, certain forms of this protein are resistant to ERAD and are eliminated through ER-phagy

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