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Hydrogen peroxide, present as superoxide radical and iron, forms a more reactive form, subsequently converted in lipid peroxide

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Although some authors have demonstrated an association between hyperhomocysteinaemia and free radical formation ( Reference Huang, Hsu and Lin 8 Reference Weiss 10 ) , the present study is the first to demonstrate that the reduction of plasma Hcy levels by creatine supplementation is associated with a significant reduction of plasma lipid peroxidation biomarkers (Table 3)