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Visual inspection of the funnel plot (Supplementary Figure 2) revealed symmetrical study distribution, suggesting minimal likelihood of publication bias or between-study systematic bias

Some providers even use topical anesthetic to make it more comfortable

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The results of a study by Poggioli et al [64] revealed that chronic administration of DEX was associated with decreased weight gain, which was attributed to its ability to accelerate fatty acid oxidation, and decrease brown adipose tissue thermogenesis and the activity of uncoupling protein-1 mRNA[64]

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However, this remains controversial as histological findings are inconsistent, and there is no definitive link established between GLP-1 and nesidioblastosis