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First, effective contraception is essential during treatment with GLP-1 receptor agonists

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The BCPNN analysis further validated these findings, demonstrating that female patients had higher risks of long-term treatment-related adverse reactions, whereas male patients experienced more acute adverse events in the short term

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A pharmacology that keeps amylin receptors tonically engaged, day and night, may reproduce amylins central appetite effects (which appear to tolerate sustained stimulation reasonably well) while behaving quite differently at the level of the stomach, where continuous braking could invite adaptive counter-regulation