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For independent practices, the risk is concentrated in a few specific scenarios: billing a mix of in-network and out-of-network plans without tracking deadlines separately, handling Medicare Advantage claims under the wrong assumption that the commercial 90-day rule applies, and missing COB secondary claim windows because the clock starts from the primary EOB rather than the date of service
Biomarkers and Metabolic Response Monitoring During Escalation Beyond symptom tolerance, providers track fasting glucose, HbA1c, lipid panels, and body composition changes to guide dose increases