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This ferroptosisinflammationhypoxia loop ultimately converges on fibrosis progression: pro-inflammatory cytokines (e.g., from activated macrophages) and hypoxic signals synergistically activate the TGF-/SmadHDAC3 pathway, downregulating anti-fibrotic Klotho and upregulating pro-fibrotic factors (e.g., collagen I/III)

It strengthens the bodys antioxidant defense, fights oxidative stress, supports a healthy immune system, aids in detoxification processes, and can contribute to skin brightening by inhibiting melanin production

Formononetin protects against cisplatin-induced acute kidney injury through activation of the PPAR/Nrf2/HO-1/NQO1 pathway

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Med 3 , 94ra70 (2011)