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Pharmacokinetic and clinical studies with levocarnitine injection have shown that administration of levocarnitine to ESRD patients on hemodialysis results in increased plasma levocarnitine concentrations

Nat Rev Cardiol 10(9):531547 Verdonschot JAJ, Hazebroek MR, Derks KWJ, Barandiarn Aizpurua A, Merken JJ, Wang P, Bierau J, van den Wijngaard A, Schalla SM, Abdul Hamid MA, van Bilsen M, van Empel VPM, Knackstedt C, Brunner-La Rocca HP, Brunner HG, Krapels IPC, Heymans SRB (2018) Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-term life-threatening arrhythmias

538,539 BR-4628, 540 PF-3882845 541 , and SM-368229 542 are nonsteroidal drugs still under exploration at present

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