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These cytokines can promote cognitive dysfunction as they are able to disrupt the blood-brain barrier (BBB), allowing proinflammatory cytokines (355) to translocate into the brain and promote inflammation ( Figure 10 )

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Takayama K, Ito K, Matsui A, Yamashita T, Kawakami K, Hirayama D et al (2021) In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics

Toxicol Sci 91 , 365371, doi: 10.1093/toxsci/kfj165 (2006)