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Wang et al., 2012)

Sexual dimorphism in neurobehavioural phenotype and gut microbial composition upon long-term exposure to structural analogues of bisphenol-a

Without sufficient L-Carnitine, this process slows down, limiting the body's ability to utilize fat for energy, potentially leading to fatigue and reduced metabolic efficiency

Dosage regimens derived from studies in healthy animals may not be accurate for diseased animals

Since there are obvious differences between rodent and human physiology, it cannot be ignored that this may have a significant impact on the efficacy and safety of (any) novel agents