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GLP-1 medications can contribute to dehydration indirectly if nausea, vomiting, diarrhea, constipation, or reduced appetite lowers fluid intake
GLP-1 receptor agonists work by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways
Drugs 32 , 9971001 (2023)
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The COR-I trial, involving 1,742 participants over 56 weeks, demonstrated 6.1% average weight loss with Contrave versus 1.3% with placebo (Greenway et al., Obesity, 2010)
Pharmacy benefit managers (PBMs) contracted with Cigna occasionally impose quantity limits or refill restrictions, capping monthly injections even if your physician determines higher doses are medically necessary
Ultimately, the best approach for you depends on your individual needs and preferences
