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Nausea, vomiting, diarrhea, and abdominal discomfort are common, particularly during the initial stages of treatment or when doctors increase their patients dose

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However, activation of the afferent branch of the vagus nerve by capsaicin or activation of the vagus nerve and ENS by exendin-4, another GLP-1RA, failed to increase NE concentrations (Fig

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The Phase 2 trials enrolled people with type 2 diabetes, not type 1

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