Mitchell KG, Ikoma N, Nelson DB, Maru DM, Erasmus JJ, Weston BR, Vaporciyan AA, Antonoff MB, Mehran RJ, Rice DC, Roth JA, Swisher SG , Sepesi B, Walsh GL, Correa AM, Das P, Blum MA, Badgwell BD, Hofstetter WL
For FIB-4, a cutoff of 1.45 was used to differentiate between control and treatment groups
This was due to downregulation of key heme enzymes, fewer porphyrin-protein aggregates, and increased autophagy
Avoid during pregnancy or breastfeeding due to insufficient safety data 3
Although selenium is a necessary nutrient, the body has a relatively low rate of excess selenium excretion because evolutionarily selenium is a fairly uncommon nutrient to encounter
Ultimately, more research studies with larger sample sizes will need to be conducted before more conclusive claims can be made about the role, if any, of MTHFR variants in disease