The core mechanism underlying the interplay between ferroptosis and pyroptosis is as follows: mitochondrial damage-associated molecular patterns released during ferroptosis, such as mitochondrial DNA and ROS, can be recognized by the NLRP3 inflammasome, leading to caspase-1 activation and subsequent cleavage of gasdermin D to form plasma membrane pores, thereby executing pyroptosis and releasing mature IL-1 and IL-18 (7376)
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NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus
Genome-wide association identifies novel etiological insights associated with parkinsons disease in african and african admixed populations
Gulewitsch, R
