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COX-1: The Physiologic State COX-1 (aka PGH synthase-1) catalyzes prostaglandin and thromboxane production in the normal, physiological state (for housekeeping mechanisms)

Response of mouse zygotes treated with mild hydrogen peroxide as a model to reveal novel mechanisms of oxidative stress-induced injury in early embryos

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GSTs directly bind and inhibit ASK1, restraining JNK/p38 signaling, while oxidant-induced changes and protein Sglutathionylation relieve this inhibition, linking GSH status to apoptosis and survival decisions