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Tissue Inhibitors of Metalloproteinases (TIMPs) TIMPs increase across all concentrations tested (0.01-100 nM)

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The pH was readjusted to 5.52 by addition of 6 M HCl and the mixture was stirred at 37 C for 48 h

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Facing the impending patent cliff and increased market competition, Merck is actively planning to diversify its product lineup and innovate within its drug development strategy