Struggling with nausea on Wegovy, Zepbound, or another GLP-1
Adding cagrilintide to tirzepatide Theoretical protocol (not clinically studied): If on tirzepatide 10-15mg: Stable on tirzepatide for 4+ weeks Continue tirzepatide at current dose Add cagrilintide 0.6mg weekly Standard cagrilintide titration to 2.4mg Rationale: Tirzepatide is dual GIP/GLP-1 (very powerful alone) Adding amylin pathway could theoretically enhance No clinical data on this combination Uncertain if additional benefit over tirzepatide alone Concerns: GI side effects may be severe (both slow gastric emptying) Tirzepatide already produces 15-22% weight loss alone Unclear if cagrilintide adds meaningful benefit Expensive combination Verdict: Wait for clinical data
Supplementation with L-carnitine and its derivatives had been previously addressed for the treatment of chemotherapy-induced adverse events such as cachexia or anorexia and organ failure[]
Here are a few supplements that Huberman recommends to address various aspects of sleep: Myoinosital (900 mg/day) : helps shorten the amount of time it takes to fall back asleep after waking up in the middle of the night
Separation of hepatoma-associated -glutamyltransferase isoenzyme on cellulose acetate media with Triton X-100 and concanavalin A
In summary, the key interactions to consider are pyridoxines reduction of levodopa and anticonvulsant efficacy, niacinamides additive effects on blood pressure, blood sugar, and gout management, and the potential need for B-vitamin repletion in patients on certain medications (diuretics, isoniazid, etc.)
