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Moreover, increased ROS and NO production and proinflammatory pathways (TNF, IL-6, and IFNG) may damage the epithelial and endothelial TJs (53)

However, the precise mechanisms by which NLRP3 is activated in response to monosodium urate crystals remain incompletely understood

Clearance of the necrotic site and regeneration through proliferation of healthy cells are necessary for complete recovery after injury, yet such recovery is likely hampered by senescent cells that can no longer proliferate

Individuals With Obesity and COVID-19: A Global Perspective on the Epidemiology and Biological Relationships

10.1021/acs.jmedchem.5b00726 J

Biochemical and Biophysical Research Communications, 430(2), 614619