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The effects of combination canagliflozin and glucagon-like peptide-1 receptor agonist therapy on intermediate markers of cardiovascular risk in the CANVAS program

Novo and Lilly arent the only players in the field: candidates like orforglipron (a non-peptide oral GLP-1) and Vikings VK2735 (being developed in both oral and injectable forms) promise to broaden access and lower cost pressures

Weight loss may plateau, blood glucose targets remain out of reach, or side effects limit long-term use

Liver: Protects against NAFLD and AFLD, reduces fibrosis and lipid peroxidation, mitigates oxidative stress, and reduces inflammation