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The CreERT-negative littermates of same age were used as controls, which showed no phenotypic difference from wild-type C57/BL6 mice

Zepbound is a combined glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for chronic weight management in adults who are obese or overweight with at least one weight-related condition, such as high blood pressure, type 2 diabetes, high cholesterol, or cardiovascular disease and is to be used in addition to a reduced calorie diet and increased physical activity

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Interestingly, in a contrast-induced nephropathy (CIN) model, type 1 diabetic rats received intravenous injection of iopromide, heme inhibited ferroptosis by activating HO-1/Nrf2 and upregulating GPX4

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