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For example, combining AI with network pharmacology can help elucidate the multi-target mechanisms of Chinese medicine in greater detail [670]

(PubMed) Virtamo J, Taylor PR, Kontto J, et al

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Chronic knee pain limits physical activity, which promotes weight gain and worsens metabolic control, which drives further systemic inflammation, which accelerates joint damage, which increases pain further

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Interestingly, hypoxia through HIF-1 significantly changes the function of MDSC in TME and shifts its differentiation direction to tumor-associated macrophages (TAMs) (286)