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simultaneously, IBD-related genetic markers (NOD2, IL23R) influence baseline gut barrier function and inflammatory state

Since GLP-1 is rapidly degraded by DPP-4 and both peripheral and central GLP-1 reduces food consumption, it has been proposed that there may be a signaling link between peripheral GLP-1R activation and central GLP-1 release from the nucleus of the solitary tract (Trapp and Hisadome, 2011)

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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)