A study published in PMC on oxidative stress in Graves' disease found that: *Hyperthyroidism is associated with increased lipid peroxidation products in thyroid and liver tissue *Glutathione peroxidase activity is upregulated in an attempt to compensate for increased ROS generation - but this compensatory response is often insufficient, leading to net oxidative damage *Antioxidant treatment may help counter some of the clinical manifestations of thyrotoxicosis by reducing ROS-driven cellular damage A review in PMC on oxidative stress in Graves' disease concluded: "These data suggest that increased ROS generation may contribute to generate some clinical manifestations of thyrotoxicosis and that antioxidant treatment may be beneficial." Selenium supplementation - acting through GPx and the glutathione system - has been shown to delay disease progression and improve quality of life in patients with Graves' orbitopathy (the eye complication of Graves' disease), as confirmed by the Frontiers in Endocrinology review
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Kaizuka, T
PubMed Central, Ponce-Ruiz, N., et al
Scotton WJ, Mollan SP, Walters T, Doughty S, Botfield H, Markey K, et al
