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Rare but serious risks of taking metformin include lactic acidosis and flu-like symptoms

doi: 10.1523/JNEUROSCI.5369-03.2004

hence diosgenin and charantin have high volume of distribution and ultimately have high t 1/2 values

10.1016/j.bcp.2017.06.112 Biochem Pharmacol

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10.1002/jnr.23065 61 KawasL