The [pre-] history of the incretin concept
Monotherapy with the once weekly GLP-1 receptor agonist dulaglutide for 12 weeks in Japanese patients with type 2 diabetes: dose-dependent effects on glycaemic control in a randomised, double-blind, placebo-controlled study
In the cardiovascular system, GLP-1R is known to exist not only on cardiomyocytes and endothelial cells, but also in the autonomic nervous system, Figure 3 suggests that GLP-1R may have direct and indirect effects on the heart and blood vessels
Marx N, Husain M, Lehrke M, Verma S, Sattar N
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Papain digestion yields two identical antigen- binding fragments, termed "Fab fragments", each with a single antigen-binding site, and a residual "Fc fragment