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Consequently, hypoxia plays a crucial role in tumor angiogenesis, and reversing the tumor hypoxic microenvironment may aid in the treatment of anti-angiogenic and tumor vascular normalization

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The cysteine residues of PDI family members such as PDI, ERp57, and ERp72 contain redox-sensitive side chains and may become oxidized during redox dysregulation (Valle and Carr, 2017)

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A study conducted on rats proved that cortisol administration increased oxidative damage to DNA material, but did not lead to an increase in the rate of production of reactive oxygen species in the liver (94)

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