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Berberine has blood sugar lowering effects similar to metformin, meaning the same hypoglycemia risks apply

In silico-based experiments on mechanistic interactions between several intestinal permeation enhancers with a lipid bilayer model

In a human trial, high-fiber diets improved sleep and even shifted chronotype earlier (toward morningness), potentially by these gut-mediated pathways (Drgoi et al., 2025

Studies finding protective effects against cancer: A meta-analysis found that two copies of the C677T variant (AA genotype) decrease the risk of colon cancer by about 20%![ref] Another meta-analysis found that two copies of the C677T variant (AA genotype) were protective against prostate cancer .[ref] The MTHFR C677T variant decreases the relative risk of retinoblastoma and oral squamous cell cancer.[ref][ref] Two copies of the C677T variant (AA genotype) are protective against gastric cancer.[ref] However, for someone who has cancer, the MTHFR C677T variant is associated with poorer outcomes.[ref] The MTHFR A1298C variant (GG or GT) is associated with a decreased risk of hypothyroidism .[ref] The flip side: Folate can also help protect against cancerous mutations in the first place

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Published in JAMA Psychiatry, the study found that more than half of patients with binge eating disorder and one third of patients with atypical anorexia nervosa reported having used GLP-1 medications