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Weight loss during weeks eight through twelve often ranges from six to twelve pounds, continuing the momentum established in earlier weeks

And while brain research into GLP-1 and reward circuits is still in its early days, its a field to watch closely

doi: 10.1007/s11154-021-09699-1

Technical details are summarized in the FDA prescribing information and independent overviews such as StatPearls (both describe the ~1-week half-life and slow elimination)