The use of engineered doxorubicin-loaded erythrocytes (DLEs) increased the drugs presence in the bloodstream and facilitated its targeted delivery to the spleen, liver, and lungs, thereby reducing the doxorubicin load on other organs (Zocchi et al., 1989
Cells 9, 2028
For example, Nrf2, a representative antioxidant gene, activates the transcription of ferritin heavy chain 1 (a protein involved in iron storage) and heme oxygenase-1 (a protein involved in heme breakdown) to reduce labile iron and regulate iron metabolism and oxidative stress [15,45]
When your stomach empties more slowly and produces less acid, B12 absorption drops
In the study by Li et al., there was no significant difference between low doses and high doses of ALA, indicating that the benefits of ALA are not dose-dependent [105]
The drug combination can also cause serotonin syndrome