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Beyond side effects, some people explore split dosing for practical reasons
Semaglutide for Obesity (NEJM, 2025) Rodriguez et al
Several studies have shown that the degree of chronic inflammatory response in PCOS is closely related to obesity, IR, and hyperandrogenism.16,52,53 On the one hand, IR not only affects normal glucose metabolism, but also promotes the synthesis of local steroid hormones in the ovaries, leading to further exacerbation of elevated circulating T levels and abnormal follicular development in PCOS patients
patients face a 6+ year wait for generic Ozempic
It hasn't been a rocket ship to weight loss, but I'm steadily losing 1-2 pounds per week, and I haven't hit a plateau yet