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Reactive astrocytes counteract oxidative stress by activating nuclear factor erythroid-2-related factor 2 (Nrf2) and releasing various antioxidant molecules, such asGSH and metallothioneins (MTs)

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Kenny HA, Lal-Nag M, White EA, Shen M, Chiang CY, Mitra AK, et al

Therefore, SIRT2 may be a causative factor of DKD and lead to disease progression (Liu S

Experimental or investigational : Medications considered experimental or investigational, lacking clinical evidence