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Unlike stimulants such as phentermine, GLP-1s may aid in weight loss while also improving blood sugar control

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doi: 10.1126/scitranslmed.aav5928 135 MelkiIAllaeysITessandierNMailhotBCloutierNCampbellRAet al

The CLOCK:BMAL1 complex activates the promoter of NAMPT, the critical enzyme of the NAD + salvage pathway, in a cyclic manner every 24 hours, increasing NAD + production