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These include: Autoimmune disorders Cerebrovascular conditions Chronic stress and untreated mental health issues Treatment-resistant depression (TRD) does not have a single strict definition, but most healthcare providers diagnose it when symptoms fail to improve after trying at least two first-line antidepressants at the proper dose and duration (typically 68 weeks each)

The most well-known are semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)

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In the obesity/diabetes model, long-term infusion of PYY (3-36) through osmotic pumps or long-acting analogues can significantly reduce obesity in gene mutant mice (leptin-deficient mice), db gene mutant mice (leptin receptor-deficient mice), Zucker diabetic fat (ZDF), and Diet-induced obesity (DIO) mice