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Nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the key transcription factors regulating antioxidant system activity

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The most commonly reported adverse effects associated with allulose consumption are gastrointestinal in nature, including bloating, abdominal discomfort, and diarrhea

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Hcy and Hcy thiolactone promote arteriosclerosis via increased oxidant stress, impaired endothelial function, and induction of thrombosis, increasing the cardiovascular disease risk in humans (43)