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Role of renal tubular programed cell death in diabetic kidney disease
10.3390/cells8040356 Cells
Cameron JC, Pakrasi HB
Some of these are small molecules that specifically inhibit the different protein complexes of the ETC, while uncoupler proteins or molecules create holes in the membrane and destroy the H+ gradient resulting from electron flow through complex I, III, and IV of the ETC
Ferroptosis is defined by a unique redox imbalance driven primarily through enzymatic or iron-dependent lipid peroxidation and loss of antioxidant membrane repair resulting in membrane rupture and cell death
15 , 23 GSH depletion in the brain is a common finding in patients with neurodegenerative conditions eg Alzheimers disease and Parkinsons disease, which can cause neurodegeneration prior to disease onset
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