Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration
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Both peptides naturally occur in the human body or are derived from naturally occurring proteins
therefore, DPP-4 inhibitors are used as glucose-lowering agents in individuals with type 2 diabetes [8]
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