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Research domain criteria (RDoC): toward a new classification framework for research on mental disorders

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To study clean GH pulsatility without endocrine noise: ipamorelin (selective GHRP, no cortisol/prolactin)

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Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats

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And 63% achieved at least 20% weight loss

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As we move toward a new era of oral therapeutics, how might this shift our long-term treatment algorithms and conversations with patients about managing obesity as the chronic disease it is?

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While some side effects may be mild, others can be more serious

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