Doseresponse relationships for both agents were nonlinear, with greater incremental effects at lower doses and attenuation at higher doses, although the shape and extent of these relationships differed between drugs
They are prescription-only medicines (POMs) subject to rigorous regulatory oversight, with clear indications, dosing schedules, and safety monitoring requirements
(verified owner) So great
This may have been the main impetus of Novos decision not to make the payment and allow the particular patent to lapse, likely not an oversight. In this view, letting the patent lapse might have simply been a low-cost calculation, especially if Novo believed their core IP protection was set to expire soon
In short, GLP-1 receptor agonists now occupy a leading position among the worlds best-selling medicines , reflecting unprecedented demand for these new diabetes and obesity treatments
If you want the simplest, lowest-cost entry point, the shot is the place to start
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