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The anti-cancer properties of biguanides are displayed through several mechanisms of action, including the activation AMPK pathway with the consequent inhibition of mTOR and reduction of several pro-tumorigenic effects including cell proliferation and production of inflammatory mediators (Seyfried et al., 2014

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I order homocysteine as a reflex test only, not routinely: if B12, folate, or B6 comes back low on the initial panel, I then request homocysteine to see whether the deficiency is translating into elevated levels that feed into my DVT risk assessment

The high levels of oxidative stress seen in these chronic inflammatory states requires a response from the bodys antioxidants, of which glutathione is the most abundant