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Formulations containing methylcobalamin (not cyanocobalamin) are preferred for patients with MTHFR polymorphisms, which affect up to 40% of the population and impair B12 activation

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Importantly, systemic trigonelline correlated positively with muscle health clinical readouts in the same cohort and with muscle strength in an Iranian cohort 124

Bioorg Med Chem Lett 22:18221826 Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann K, Cai LL, Niehues M, Badock V, Kramm A, Chen S, Hillig RC, Clemons PA, Gradl S, Montagnon C, Lazarski KE, Christian S, Bajrami B et al (2020) Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

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