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the FDA has stated it lacks sufficient information to know whether the substance would cause harm when administered to humans Evidence snapshot: The evidence base is almost entirely preclinical, decades of animal (largely rat) studies, mostly from one Croatian research group (Sikiric et al., University of Zagreb), with a single small human trial under the brand name "Bepecin" (around 2015) that did not lead to any FDA-approved use

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Human study groups were generally very small

Because B12 is involved in converting carbohydrates, fats, and proteins into adenosine triphosphate (ATP)the body's primary energy currencysome assume that supplementation will "boost metabolism" or increase energy expenditure

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10.1023/A:1015557300450 168 WahibahN